This is perhaps one of Shakespeare's more interesting plays, if you will. In comparison to Macbeth it isn't quite the walk in the park.
I think conceptually it enables the reader to see that characters can influence characters to such a degree that the original traits are masked and changed. Tragedy in this play is definitely a main component - and a great emphasis that perhaps the villain doesn't always find their true defeat. In a way, wasn't the "villain" successful? He lied to everyone and pretty much killed whomever got in his way.
Cleopatra's sexuality, despite condemnation by the patriarchal men - she is referred to as 'strumpet' and 'whore' on various occasions throughout the play - is unhidden and unrestricted. Her sexual power over men is conveyed boldly, for example, in her descriptions of her former conquests 'great Pompey' and 'Broad-fronted Caesar'. Cleopatra's sexuality is not a thing to be locked up, as in Hamlet and Othello , but is celebrated as a positive force. Surprisingly, even Enobarbus, despite his patriarchal views, does on occasions present her as positively sexual, as his unforgettable description of her indicates: